UCL-3500 UV Crosslinker – More Power. More Room. More Results.

The UCL-3500 UV Crosslinker delivers higher irradiance and a larger chamber capacity—engineered for high-throughput molecular biology workflows that demand speed and consistency. From nucleic acid membrane crosslinking and protein-RNA interaction studies to UV curing and induced mutagenesis, this microprocessor-controlled system brings precision to every application.

At its core, a programmable microprocessor continuously monitors UV output in real time, ensuring reproducible results run after run. The spacious irradiation chamber guarantees uniform light distribution across the entire sample area.

Key Features

Uniform UV illumination: Features an array of six 15-W UV lamps and optimized reflection design to ensure even UV distribution throughout the chamber, delivering consistent results.

High-capacity chamber: Process multiple samples in a single run for enhanced throughput and time savings.

Microprocessor-controlled intelligence: Equipped with a programmable microprocessor that monitors and displays UV intensity in real time for precise and reproducible experiments.

Three operating modes: Supports energy mode, time mode, and preset mode to accommodate various experimental requirements.

Rapid startup with memory: Startup time < 1 second; retains the last used program and allows one-touch start upon power-on.

Intuitive interface: Provides clear and real-time readouts for user-friendly operation.

Audible alert and auto-standby: Emits a beep upon crosslinking completion and automatically enters standby mode for safety and energy savings.

Safety interlock system: Automatically shuts off UV exposure when the chamber door is opened, protecting operators from accidental UV exposure.

Technical Data

The UCL-3500 Series UV Crosslinkers are equipped with six 15‑W tubes and are available in three wavelengths: 254 nm, 302 nm, or 365 nm.

UCL-3500 UV Crosslinker Applications

• Nucleic Acid Crosslinking and Membrane Immobilization

• Protein Crosslinking and Protein-Protein Interaction Studies

• Protein-DNA and Protein-RNA Interaction Studies

• Polymer Curing and Material Crosslinking

• Controlling PCR Contamination

• Gene Mapping and UV-induced Mutagenesis

• UV Sterilization and Sanitation

• Screening for RecA mutations in Escherichia coli

Publications

Yan, S., Tang, Z., Pan, B., Chen, X., Zhang, B. & Lu, J. Synergistic Aging Resistance and Autonomous Self-Healing in Trimethylolpropane Triglycidyl Ether-Based Anti-Icing Coatings. Coatings 16, 13 (2026).

Ma, T., Feng, P., Xu, Y., Guo, X., Wang, M., Ye, F. & Fang, Y. Screening of high-yielding β-farnesene Saccharomyces cerevisiae strains and quantification of fermentation processes: A new fluorescence-based high-throughput screening and quantification platform. Biochem. Eng. J. 226, 110006 (2026).

Zhao, N., Zhou, X., Li, Z., Liang, L., Bao, J., Chen, X., Shu, P. & Zhong, J. Selaginella Tamariscina extract reduces UVA-induced skin photodamage via regulating apoptosis and autophagy by AKT phosphorylation. J. Photochem. Photobiol. B: Biol. 274, 113343 (2026).

Li, Y., Zhang, J., Xiang, Z., Wang, J., Ren, S., Zhao, J., Fu, D. & Wang, Y. Dual-mode nitric oxide releasing vascular grafts for vascular homeostasis and antibacterial defense. Acta Biomater. 206, 239–255 (2025).

Yang, C., Xu, Y., Liu, H., Yan, K., Wang, W., Zhao, Q. & Wang, D. Multiscale Porous Heat Insulation Polypropylene Foam with High Infrared Absorption Performance. Langmuir 41, 5546–5556 (2025).

Zhong, J., Liang, L., Zhao, N., Wang, J. & Shu, P. Synergistic effects of retinol and retinyl palmitate in alleviating UVB-induced DNA damage and promoting the homologous recombination repair in keratinocytes. Front. Pharmacol. 16, 1562244 (2025).